Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide

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成果类型：

期刊论文

作者：

Chen, Ying;Zhou, Cheng-Fang;Xiao, Fan;Huang, Hong-Lin*;Zhang, Ping;...

通讯作者：

Tang, Xiao-Qing;Huang, Hong-Lin

作者机构：

[Tang, Xiao-Qing; Chen, Ying; Huang, Hong-Lin] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

[Gu, Hong-Feng; Xiao, Fan; Tang, Xiao-Qing; Chen, Ying; Zhou, Cheng-Fang] Univ South China, Coll Med, Inst Neurosci, Hengyang, Hunan, Peoples R China.

[Zhang, Ping] Univ South China, Dept Neurol, Nanhua Affiliated Hosp, Hengyang, Hunan, Peoples R China.

[Huang, Hong-Lin] Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Huang, Hong-Lin] U

Univ South China, Coll Med, Inst Neurosci, Hengyang, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

aldehyde-dehydrogenase-2;formaldehyde;hydrogen sulphide;neurotoxicity;PC12 cells

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2017

卷：

期：

页码：

595-601

DOI：

10.1111/1440-1681.12741

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471310]; Zhengxiang Scholar Program of University of South China [2014-004]; Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Formaldehyde (FA), a common environmental contaminant, has toxic effects on the central nervous system (CNS). We have previously found that hydrogen sulphide (H2S), the third endogenous gaseous mediator, protects neuron against the toxicity of FA. However, the underlying mechanism is poor. Aldehyde-dehydrogenase-2 (ALDH2) plays a major role in detoxification of reactive aldehyde in a range of organs and cell types. Therefore, we speculated that H2S antagonizes FA-induced neurotoxicity by modulating ALDH2. In the present study, we found that the exposure of PC12 cells to FA causes increase in A...

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Inhibition of ALDH2 protects PC12 cells against formaldehyde-induced cytotoxicity: involving the protection of hydrogen sulphide

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