期刊论文

Roles of P2X7 receptor and NLRP3 inflammasome in inflammatory diseases

中文

中华微生物学和免疫学杂志

0254-5101

2023

4

316-321

国家自然科学基金(31872643)。

本校为第一机构

嘌呤能2X7受体(purinergic 2X7 receptor, P2X7R)是一种离子通道型受体, 可引起核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization doma...展开更多 嘌呤能2X7受体(purinergic 2X7 receptor, P2X7R)是一种离子通道型受体, 可引起核苷酸结合寡聚化结构域样受体3(nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3)的激活, 进而影响炎症细胞因子如IL-1β、IL-18等的释放从而参与多种炎症性疾病。近年来, P2X7R/NLRP3信号通路已成为炎症性疾病研究较多的通路之一, 已有部分P2X7R和NLRP3炎性小体的拮抗剂进入早期的临床治疗。本文就P2X7R和NLRP3炎性小体...

Purinergic 2X7 receptor(P2X7R)is an ionotropic receptor that is involved in various inflammatory diseases through affecting the release of inflammatory cytokines such as IL-1βand IL-18 after inducing the activation of nucleotide-binding oligomerization domain-like recep...MORE Purinergic 2X7 receptor(P2X7R)is an ionotropic receptor that is involved in various inflammatory diseases through affecting the release of inflammatory cytokines such as IL-1βand IL-18 after inducing the activation of nucleotide-binding oligomerization domain-like recep...