Targeting STING for cancer immunotherapy: From mechanisms to translation

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成果类型：

期刊论文

作者：

Huang, Ruilei;Ning, Qian;Zhao, Jihui;Zhao, Xuhong;Zeng, Luting;...

通讯作者：

Tang, Shengsong

作者机构：

[Zhao, Jihui; Tang, Shengsong; Zeng, Luting; Zhao, Xuhong; Ning, Qian; Huang, Ruilei; Yi, Yi] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

[Tang, Shengsong] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Peoples R China.

[Tang, Shengsong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Shengsong Tang] H

Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China<&wdkj&>College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China

语种：

英文

关键词：

Cancer immunity cycle;Cancer immunotherapy;STING agonists

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2022

卷：

113

期：

Pt A

页码：

109304

DOI：

10.1016/j.intimp.2022.109304

基金类别：

We are very grateful for the support of the Hunan Provincial Science and Technology Plan Key Projects of China (2017SK2183), the Scientific Research Project of Hunan Provincial Health Commission (202113022028) and the Scientific Research Fund of Hunan Provincial Education Department (21C1379 and 20C1329).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Cancer immunotherapy with immune checkpoint inhibitors has achieved unprecedented success in cancer treatment; However, only a subset of patients achieved clinical benefit from this treatment, underscoring the urgent need to identify new strategies to enhance the clinical efficacy of immune checkpoint inhibitors. Given the essential role of innate immunity in cancer immune surveillance, tremendous effort has been focused on the innate immune pathways that can be pharmacologically modulated to improve the clinical outcome of checkpoint inhibitors. The cyclic GMP-AMP synthase (cGAS)-stimulator o...

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