α-Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3-Mediated Pyroptosis of Granulosa Cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Ke;Wu, Yafei;Li, Tianlong;Wang, Zhongxu;Xiao, Shu;...

通讯作者：

Chen, Xi;Lei, XC;Zhang, S

作者机构：

[Li, Tianlong; Chen, Xi; Li, Meng; Lei, Xiaocan; Wang, Zhongxu; Li, Meixiang; Liu, Ke; Chen, X; Xiao, Shu; Peng, Zhenghua; Wu, Yafei] Univ South China, Inst Clin Anat & Reprod Med, Hengyang Med Sch, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Xiong, Wenhao] Univ South China, Inst Cardiovasc Dis, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Shun; Zhang, S] Guilin Med Univ, Affiliated Hosp, Med Ctr, Dept Reprod, Guilin 541001, Guangxi, Peoples R China.

通讯机构：

[Lei, XC ; Chen, X] U

[Zhang, S ] G

Univ South China, Inst Clin Anat & Reprod Med, Hengyang Med Sch, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

Guilin Med Univ, Affiliated Hosp, Med Ctr, Dept Reprod, Guilin 541001, Guangxi, Peoples R China.

语种：

英文

关键词：

alpha-ketoglutarate;granulosa cell;ovarian reserve;premature ovarian insufficiency;pyroptosis

期刊：

MOLECULAR NUTRITION & FOOD RESEARCH

ISSN：

1613-4125

年：

2024

卷：

期：

页码：

e2300784

DOI：

10.1002/mnfr.202300784

基金类别：

National Natural Science Foundation of China; Natural Science Foundation of Guangxi in China [2020GXNSFAA297097]; Natural Science Foundation of Hunan Province [2021JJ30021, 2022JJ30503]; Scientific Research Foundation of Hunan Provincial Education Department [20A434, 20B501]; Research and Innovation Program for Graduate Students of Hunan Province [QL20230239]; National Training Program of Innovation and Entrepreneurship for Undergraduates [X202110555521]; [82101720]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

AKG protects against CTX‐induced POI by inhibiting NLRP3‐mediated pyroptosis of granulosa cells, restoring the glycolysis and improving ovarian reserve function.(Created with BioRender.com). Scope Premature ovarian insufficiency (POI) is a common female infertility problem, with its pathogenesis remains unknown. The NOD‐like receptor family pyrin domain‐containing 3 (NLRP3)‐mediated pyroptosis has been proposed as a possible mechanism in POI. This study investigates the therapeutic effect of α‐ketoglutarate (AKG) on ovarian reserve funct...

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α-Ketoglutarate Improves Ovarian Reserve Function in Primary Ovarian Insufficiency by Inhibiting NLRP3-Mediated Pyroptosis of Granulosa Cells

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