期刊论文

Yi Yang

英文

International Immunopharmacology

1567-5769

2025

157

114777

10.1016/j.intimp.2025.114777

CRediT authorship contribution statement Yang Cheng: Writing – review & editing, acquisition, Data curation, Conceptualization. Yuan Xiao: Writing – original draft, Resources, Methodology, Investigation, Conceptualization. De-Ming Wang: Visualization, Validation, Supervision, Conceptualization. Kun Liu: Validation, Investigation. Xiu Yang: Validation, Methodology, Investigation. Chuang-Xin Zheng: Project administration, Methodology, Investigation, Conceptualization. Zhen-Biao He: Visualization, Validation, Investigation. Ze-Yu This work was supported by the Natural Science Foundation of Hunan Province (2025JJ81005, 2025JJ81022), Health Research Project of Hunan Provincial Health Commission (202217014497, B202317018313) and Doctoral Research Startup Fund Project of the Second Affiliated Hospital of University of South China (2021B03).

本校为第一且通讯机构

Objectives Dysregulated inflammatory responses during sepsis often result in acute lung injury (ALI). Neutrophils activated at the primary site of injury can re-enter the circulation through reverse transendothelial migration (rTEM), subsequently infiltrating other organs and contributing to systemic inflammation and multi-organ damage. The specialized pro-resolving lipid mediator (SPM) maresin conjugate in tissue regeneration 1 (MCTR1) has been shown to mitigate organ injury in sepsis. This study investigated the role of neutrophil rTEM in ALI and examined whether MCTR1 can alleviate ALI by m...