Visfatin has been seen as a biomarker in several kinds of cancers.However,no evidence has been reported for the direct effect of visfatin on osteosarcoma cells metastasis.The aims of this study were to investigate the influence of visfatin on the migration and invasion of osteosarcoma cells and clarify the underlying mechanism.The expressions of epithelial-mesenchymal transition(EMT)markers,as well as the transcriptional factor Snail1,were firstly detected at both protein and mRNA levels after the stimulation of visfatin.And then the expres...
