Molecular determinants of substrate specificity in the efflux pump CraA from Acinetobacter baumannii

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Foong, Wuen Ee;Xiang, Xinxin;Pos, Klaas M.*;Tam, Heng-Keat

通讯作者：

Tam, HK;Pos, Klaas M.

作者机构：

[Tam, Heng-Keat; Tam, HK; Foong, Wuen Ee; Xiang, Xinxin] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

[Tam, Heng-Keat; Tam, HK; Foong, Wuen Ee] Univ South China, Hengyang Med Sch, Dept Med Microbiol, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang, Hunan, Peoples R China.

[Tam, Heng-Keat; Tam, HK; Foong, Wuen Ee; Pos, Klaas M.; Pos, KM] Goethe Univ Frankfurt, Inst Biochem, Frankfurt, Germany.

[Tam, Heng-Keat; Tam, HK] Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha, Hunan, Peoples R China.

通讯机构：

[Tam, HK ] U

[Pos, KM] G

Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang, Hunan, Peoples R China.

Univ South China, Hengyang Med Sch, Dept Med Microbiol, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang, Hunan, Peoples R China.

Goethe Univ Frankfurt, Inst Biochem, Frankfurt, Germany.

语种：

英文

关键词：

Acinetobacter baumannii;multidrug resistance;efflux pumps;major facilitator superfamily;substrate polyspecificity

期刊：

MICROBIOLOGY SPECTRUM

ISSN：

2165-0497

年：

2025

卷：

期：

页码：

e0111925

DOI：

10.1128/spectrum.01119-25

基金类别：

Deutsche Forschungsgemeinschaft

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

The major facilitator superfamily (MFS) type efflux pumps of Acinetobacter baumannii play important roles in antibiotic resistance. However, the molecular mechanism of these transporters remains poorly understood. To address the molecular basis of substrate polyspecificity mediated by multidrug MFS transporters, we compared the substrate binding modes of A. baumannii CraA with its well-studied homolog, Escherichia coli MdfA. MdfA and CraA share similar structural features, including a cavity accessible to drugs from the cytoplasm when these transporters adopt the inside-out conformation. This ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Molecular determinants of substrate specificity in the efflux pump CraA from Acinetobacter baumannii

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问