Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis

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成果类型：

期刊论文

作者：

Huang, Xiangping;Wu, Ling;Ouyang, Qianhui;Huang, Ying;Hong, Lanhui;...

通讯作者：

Tan, CC

作者机构：

[Wu, Ling; Ouyang, Qianhui; Huang, Xiangping; Hong, Lanhui] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Clin Lab, Affiliated Hosp 1, 61 Jiefang Rd, Changsha 410005, Hunan, Peoples R China.

[Liu, Sixiang; Huang, Ying] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Emergency, Changsha, Hunan, Peoples R China.

[Yang, Kongzhi; Ning, Ding] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Emergency Med, Changsha, Hunan, Peoples R China.

[Tan, Chao Chao; Tan, CC] Hunan Prov Peoples Hosp, Hunan Prov Geriatr Inst, Tumor Immun Res Ctr, Changsha, Hunan, Peoples R China.

[Tan, Chao Chao; Tan, CC] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Clin Lab, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

通讯机构：

[Tan, CC ] H

Hunan Prov Peoples Hosp, Hunan Prov Geriatr Inst, Tumor Immun Res Ctr, Changsha, Hunan, Peoples R China.

Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Clin Lab, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Neutrophil CD64 index;Infected pancreatic necrosis;Acute pancreatitis

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2024

卷：

期：

页码：

1-11

DOI：

10.1186/s12967-024-04901-9

基金类别：

This study was funded by Grants from China National Natural Science Fund (81600502), Natural Science Foundation of Hunan Province (2020JJ8086, 2023JJ10024), Project of Hunan Provincial Health Commission (202103031672), Doctoral Program of Hunan Provincial People’s Hospital (BSJJ202004), and Project of Hunan Provincial Education Department (22A0075), Key Cultivation Project of Renshu Fund of Hunan Provincial People’s Hospital (RS2022A15), Project of Hunan Province Science and Technology Department (2020SK3042).

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摘要：

OBJECTIVE: Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to investigate the predictive capacity of the neutrophil CD64 index (nCD64 index) on IPN in patients with acute pancreatitis METHODS: This study comprises two independent cohorts: the training cohort consisted of 202 patients from Hunan Provincial People's Hospital, and the validation cohort consisted of 100 patients from Changsha...

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Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis

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