MiR-210 Links Hypoxia With Cell Proliferation Regulation in Human Laryngocarcinoma Cancer

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成果类型：

期刊论文

作者：

Zuo, Jianhong;Wen, Meiling;Lei, Mingsheng;Peng, Xiang;Yang, Xuefeng*;...

通讯作者：

Yang, Xuefeng

作者机构：

[Zuo, Jianhong; Liu, Zhigang] Shenzhen Univ, Sch Med, State Key Lab Resp Dis Allergy, Shenzhen 518060, Guangdong, Peoples R China.

[Zuo, Jianhong; Wen, Meiling; Yang, Xuefeng] Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

[Zuo, Jianhong] Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Lei, Mingsheng] Zhangjiajie City Hosp, Dept Resp & Crit Care Med, Zhangjiajie 427000, Hunan, Peoples R China.

[Peng, Xiang] Shenzhen Univ, Sch Optoelect, Shenzhen 518060, Guangdong, Peoples R China.

通讯机构：

[Yang, Xuefeng] U

Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MiR-210;HYPOXIA;CELL PROLIFERATION;LARYNGOCARCINOMA CANCER;FGFRL1

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2015

卷：

116

期：

页码：

1039-1049

DOI：

10.1002/jcb.25059

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272960]; Key Research Program from Science and Technology Department of Hunan Province China [2013WK2010]; Research Program from Education Department of Hunan Province China [12C0343]; Research Program from Health Department of Hunan Province China [B2012-047]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

ABSTRACT The microRNA hsa‐miR‐210 (miR‐210) is associated with hypoxia; however its function has not fully identified. In the present study, we aim to detect its role concerning proliferation in Laryngocarcinoma. We found that miR‐210 was highly expressed in hypoxia, which inhibited proliferation by inducing cell cycle arrest in G1/G0 as well as apoptosis. We further identified that miR‐210 targeted fibroblast growth factor receptor‐like 1 (FGFRL1). Down regulation of FGFRL1 decreased cell proliferation by promoting proportion of cells in...

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MiR-210 Links Hypoxia With Cell Proliferation Regulation in Human Laryngocarcinoma Cancer

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