期刊论文

Progress of Small Animal PET Scanners with High Spatial Resolution and High Sensitivity

中文

原子核物理评论

1007-4627

2016

33

3

336-344

10.11804/NuclPhysRev.33.03.336

国家自然科学基金资助项目（81527804,11575285,81401410） 深圳市基础研究项目（JCYJ20140417113430558,JCYJ-20150630114942310）

本校为其他机构

作为一种高灵敏度且具有定量测量能力的功能分子影像技术,小动物PET越来越广泛地用于各种生物医学研究,例如疾病动物模型研究、新药物研发和新治疗方法评估等。首先回顾小动物PET成像系统的发展历史、效率和空间分辨率等性能的改进和产业化;其次,讨论了影响PET空间分辨率和效率的各种因素,包括晶体大小、探测器几何、正电子射程、光子非共线效应、图像重建算法和阻碍PET系统同时达到高空间分辨率和高效率的相互作用深度不确定效应;最后,介绍了小动物PET成像系统在以下几个方面的取得的最新进展:(1)高密度、小的光衰减常数和高光产额的闪烁晶体;(2)体积小、增益大、时间性能好、工作电压低和磁兼...

As the most sensitive and quantitative molecular imaging technique, small animal positron emission tomography (PET) has become a widely used tool in biomedical research such as in animal model of human disease, development of new drugs and the evaluation of new therapeutics. In this paper, first the history,the efforts to improve the spatial resolution and sensitivity as well as the commercialization process of small animal PET scanner are reviewed. Then the factors that affect the spatial resolution and sensitivity of PET scanner such as cryst...