We use Geant4 toolkit to model high-energy proton irradiating spallation target in an Accelerator-Driven sub-critical System (ADS). The simulated neutron leakage spectrum resulting from proton bombarding liquid metal targets of lead, lead-bismuth eutectic, and hydrargyrum are obtained. The neutron leakage yields from lead target and their axial integrated distributions are calculated with different incident proton energies. Considering the incident proton e?ciency and the whole size and mass of the reactor core, the optimized target radius and ...