A PEDOT enhanced covalent organic framework (COF) fluorescent probe for in vivo detection and imaging of Fe3+

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成果类型：

期刊论文

作者：

Zhen, Deshuai;Zhang, Shaoqi;Yang, Aofeng;Li, Le;Cai, Qingyun;...

通讯作者：

Liu, Y

作者机构：

[Liu, Yu; Zhang, Shaoqi; Li, Le; Zhen, Deshuai; Yang, Aofeng] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Liu, Yu; Zhang, Shaoqi; Zhen, Deshuai] Hunan Univ, Sch Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Grimes, Craig A.] Flux Photon Corp, 5950 Shiloh Rd East, Alpharetta, GA 30005 USA.

[Liu, Yu] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.

通讯机构：

[Liu, Y ] H

Hunan Univ, Sch Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Covalent organic framework;Fluorescent probe;In vivo imaging

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2024

卷：

259

期：

Pt 1

页码：

129104

DOI：

10.1016/j.ijbiomac.2023.129104

基金类别：

CRediT authorship contribution statement Deshuai Zhen: Conceptualization, Formal analysis, acquisition, Methodology. Shaoqi Zhang: Investigation, Writing – original draft. Aofeng Yang: Data curation, Investigation. Le Li: Investigation. Qingyun Cai: Supervision. Craig A. Grimes: Resources, Supervision, Writing – review & editing. Yu Liu: Formal analysis, Project administration.

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Simple and accurate in vivo monitoring of Fe(3+) is essential for gaining a better understanding of its role in physiological and pathological processes. A novel fluorescent probe was synthesized via in situ solid-state polymerization of 3,4-ethylenedioxythiophene (PEDOT) in the pore channels of a covalent organic framework (COF). The PEDOT@COF fluorescent probe exhibited an absolute quantum yield (QY) 3 times higher than COF. In the presence of Fe(3+) the PEDOT@COF 475nm fluorescence emission, 365nm excitation, is quenched within 180s. Fluores...

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A PEDOT enhanced covalent organic framework (COF) fluorescent probe for in vivo detection and imaging of Fe3+

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