Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

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成果类型：

期刊论文

作者：

Yan, Bin;Liu, Shuang*;Shi, Ying;Liu, Na;Chen, Ling;...

通讯作者：

Liu, Shuang;Tao, Yongguang

作者机构：

[Tao, Yongguang; Liu, Shuang; Muegge, Kathrin; Yan, Bin] Cent S Univ, Xiangya Hosp, Inst Med Sci, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Tao, Yongguang; Liu, Shuang; Muegge, Kathrin; Liu, Xiaoli; Mao, Chao; Lai, Weiwei; Yan, Bin; Shi, Ying; Jiang, Yiqun; Xin, Xing; Liu, Yating; Liu, Na; Cao, Ya; Yang, Rui; Chen, Ling] Cent S Univ, Xiangya Hosp, Minist Educ, Key Lab Carcinogenesis & Canc Invas, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Tang, Can-E; Tao, Yongguang; Muegge, Kathrin; Liu, Xiaoli; Mao, Chao; Lai, Weiwei; Yan, Bin; Shi, Ying; Jiang, Yiqun; Xin, Xing; Liu, Yating; Liu, Na; Cao, Ya; Yang, Rui; Chen, Ling] Cent S Univ, Canc Res Inst, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

[Tao, Yongguang; Muegge, Kathrin; Wang, Xiang] Cent S Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha, Hunan, Peoples R China.

[Xiao, Desheng] Cent S Univ, Xiangya Hosp, Dept Pathol, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Liu, S; Tao, YG] C

Cent S Univ, Xiangya Hosp, Inst Med Sci, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp, Minist Educ, Key Lab Carcinogenesis & Canc Invas, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2018

卷：

期：

页码：

490

DOI：

10.1038/s41419-018-0542-9

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2015CB553903]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672787, 81372427, 81672991, 81271763, 81302354, 81422051, 81472593]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2013ZZTS074]; Frederick National Laboratory for Cancer ResearchUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HHSN261200800001E]; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [ZIABC010014, ZIABC010014, ZIABC010014] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Most cancer patients receive radiotherapy in the course of their disease and the occurrence of radioresistance is associated with poor prognosis. The molecular pathways that drive enhanced tumorigenic potential during the development of radioresistance are poorly understood. Here, we demonstrate that aryl hydrocarbon receptor (AhR) plays a vital role in the maintenance of cancer stem-like properties. AhR promotes the cancer stem-like phenotype and drives metastasis by directly targeting the promoters of 'stemness' genes, such as the ATP-binding...

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Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance

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