Causal Effects of Circulating Lipid Traits on Epithelial Ovarian Cancer: A Two-Sample Mendelian Randomization Study

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成果类型：

期刊论文

作者：

Meng, Hongen;Wang, Rong;Song, Zijun;Wang, Fudi

通讯作者：

Fudi Wang

作者机构：

[Meng, Hongen; Wang, Rong; Song, Zijun; Wang, Fudi] Zhejiang Univ, Affiliated Hosp 4, Affiliated Hosp 1, Inst Translat Med,Sch Med,SchPubl Hlth,Canc Ctr,St, Hangzhou 310030, Peoples R China.

[Meng, Hongen] Zhejiang Univ, Liangzhu Lab, Med Ctr, 1369 West Wenyi Rd, Hangzhou 311121, Peoples R China.

[Wang, Fudi] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang 421001, Peoples R China.

通讯机构：

[Fudi Wang] T

The First Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou 310030, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

circulating lipid;apolipoprotein;triglyceride;Mendelian randomization;epithelial ovarian cancer

期刊：

Metabolites

ISSN：

2218-1989

年：

2022

卷：

期：

页码：

1175-

DOI：

10.3390/metabo12121175

基金类别：

This research was funded by the National Natural Science Foundation of China (grant No.: 31930057 to F.W.) and the National Key R&D Program of China (grant No.: 2018YFA0507802 to F.W.).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Ovarian cancer (OC), and particularly epithelial OC (EOC), is an increasing challenge for women. Circulating lipids play different roles in the occurrence and development of OC, but no causal relationship has been confirmed. We used two-sample Mendelian randomization (MR) to evaluate the genetic effects of circulating Apolipoprotein A1 (APOA1), Apolipoprotein B (APOB), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyc-erides (TG) on EOC risks based on summary data obtained from the UK Biobank and...

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Causal Effects of Circulating Lipid Traits on Epithelial Ovarian Cancer: A Two-Sample Mendelian Randomization Study

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