Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

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成果类型：

期刊论文

作者：

Tang, Hailin;Kong, Yanan;Guo, Jiaoli;Tang, Yi;Xie, Xinhua;...

通讯作者：

Su, Qi

作者机构：

[Tang, Hailin; Xie, Xinhua; Yang, Lu; Xie, Xiaoming; Kong, Yanan; Guo, Jiaoli] Sun Yat Sen Univ, Ctr Canc, Dept Breast Oncol, Guangzhou 510060, Guangdong, Peoples R China.

[Tang, Hailin; Xie, Xinhua; Yang, Lu; Xie, Xiaoming; Kong, Yanan; Guo, Jiaoli] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China.

[Tang, Hailin; Su, Qi; Tang, Yi] Univ South China, Canc Res Inst, Hengyang, Hunan, Peoples R China.

[Su, Qi] Sun Yat Sen Univ, Ctr Canc, Dept Breast Oncol, State Key Lab Oncol South China, 651 East Dongfeng Rd, Guangzhou 510060, Guangdong, Peoples R China.

通讯机构：

[Su, Qi] S

Sun Yat Sen Univ, Ctr Canc, Dept Breast Oncol, State Key Lab Oncol South China, 651 East Dongfeng Rd, Guangzhou 510060, Guangdong, Peoples R China.

语种：

英文

关键词：

Diallyl disulfide;Gastric cancer;MicroRNA;Wnt-1 signaling pathway

期刊：

Cancer Letters

ISSN：

0304-3835

年：

2013

卷：

340

期：

页码：

72-81

DOI：

10.1016/j.canlet.2013.06.027

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31100935, 81272514]; Key Program of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31030061]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M520075]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The purpose of this study was to identify a mechanism related to miRNA pathway which plays a role in the anti-tumor effects of Diallyl disulfide. Alterations in miRNA expression were observed in Diallyl disulfide-treated MGC-803 cells, including up-regulation of miR-200b and miR-22 expression. Furthermore, Wnt-1 was identified as a target of both miR-200b and miR-22. MiR-200b and miR-22 not only synergistically inhibited gastric cancer growth, but also enhanced the antitumor effect of Diallyl disulfide both in vitro and in vivo. It indicated th...

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Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22

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