Transcription of seven genes in a model of interferon-gamma-induced persistent Chlamydia psittaci infection

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成果类型：

期刊论文

作者：

Chen, Zhixi;Chen, Lili;Wang, Chuan;Yu, Jian;Bai, Qinqin;...

通讯作者：

Wu, Yimou

作者机构：

[Yu, Jian; Wu, Yimou; Bai, Qinqin; Hu, Yanqun; Chen, Lili; Song, Yin; Yu, Minjun; Wang, Chuan; Chen, Zhixi] Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Zhixi] Univ South China, Affiliated Hosp 1, Blood Transfus Dept, Hengyang 421001, Hunan, Peoples R China.

[Wu, Yimou; Chen, Lili; Wang, Chuan; Chen, Zhixi] Univ South China, Hunan Cooperat Innovat Ctr Mol Target New Drug St, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Med Coll, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;persistent infection;interferon-gamma;gene transcription

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2017

卷：

期：

页码：

4835-4842

DOI：

10.3892/mmr.2017.7133

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270218, 81572011]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The obligate intracellular bacterium Chlamydia psittaci is the causative agent of psittacosis in birds and humans. The capability of this zoonotic pathogen to develop a persistent phase may serve a role in the chronicity of infections, in addition to the failure of antibiotic therapy or immunoprophylaxis. In the present study, a C. psittaci strain 6BC persistent infection cell model was induced using interferon (IFN)-gamma, alterations in the infectivity and morphology of the pathogen were analyzed, and the transcript profile of seven selected genes was analyzed. Following treatment with IFN-g...

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Transcription of seven genes in a model of interferon-gamma-induced persistent Chlamydia psittaci infection

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