期刊论文

mTOR Signaling Pathway and Autophagy in Tumors

中文

现代生物医学进展

1673-6273

2016

16

7

1372-1374

10.13241/j.cnki.pmb.2016.07.041

本校为第一机构

自噬是以细胞内自噬体形成为特征,通过溶酶体吸收降解自身受损细胞器和大分子的一种自我消化过程,是细胞维持稳态的重要机制。自噬广泛参与多种重要的细胞功能,既能在代谢应激状态下保护受损细胞,又可能因为过度激活导致细胞发生II型程序性死亡,从而引发多种疾病,尤其对肿瘤的发生和发展更是发挥着"双刃剑"的作用。自噬通过多种分子信号机制调控肿瘤进程,包括mTOR依赖性和mTOR非依赖性途径。mTOR作为生长因子、能量和营养状态的感受器,可通过调节下游自噬复合物的形成,直接调控细胞自噬。阐明mTOR与细胞自噬的相互作用机制将有助于从分子水平上对各肿瘤病变进行分析和治疗。因此,本文就自噬与PI...

Autophagy is a self-digestion process characterized by autophagosome formation,wrapping cytoplasmic damaged organelles and macromolecules to form vesicles and degradation in lysosome, providing an important mechanism for cells to maintain homeostasis. Autophagy is widely involved in a variety of important cellular functions. It can not only protect damaged cells from metabolic stress, but also induce the type II programmed cell death because of it＇s excessive activation, causing a variety of diseases.Moreover, it plays a ＂double-edged sword＂...