期刊论文

中文

现代生物医学进展

1673-6273

2015

15

31

6190-6193

10.13241/j.cnki.pmb.2015.31.052

14JJ2084:湖南省自然科学基金 2013KJ04:衡阳市科技计划 :南华大学十二五科技创新团队项目

本校为第一机构

神经生长因子是神经营养因子家族成员之一,对不同时期神经元的存活、分化、生长及损伤后的修复和再生都有着十分重要的作用。不仅在神经系统中,随着人类的其他正常和肿瘤组织中同样也检测得到了NGF,神经生长因子在各方面的应用也得到了重视并均已得到了证实。NGF功能的发挥离不开与其受体的结合,根据NGF表面糖蛋白与凝集素结合能力的不同,其受体可被分为高亲和力受体酪氨酸激酶A和低亲和力受体p75。Trk A与NGF结合后所介导的信号通路主要有：①MAPK通路;②PLC-γ通路;③PI3K/PKB通路。而p75与NGF结合介导的信号传导通路主要包括：①NF-κB通路;②JNK-p53-Bax凋亡通路;③神经酰胺通路。Trk A一般...

Nerve growth factor（NGF） is one of the members of the neurotrophin family, it plays an important role in survival,differentiation, growth as well as repair and regeneration after injury of neuron in different periods. NGF has been detected in nervous system as well as in other normal or tumor tissues of human. The applications of NGF were already confirmed and paid more attention.The function of NGF cannot be performed without combining with its receptors. NGF receptors can be divided into two structurally different types according to the bin...