期刊论文

中文

现代生物医学进展

1673-6273

2011

11

5

850-853

10.13241/j.cnki.pmb.2011.05.035

湖南省科技厅科研基金课题（2008FJ3221）；

本校为第一机构

目的:探讨经皮肾镜碎石术肾盂灌注冲洗压对肾脏结构和功能的影响.方法:建立20头活体猪高压肾孟冲洗模型,建立24F肾造瘘通道,分别在0mmHg(作自身对照,只造瘘不灌注)、150mmHg、200mmHg、250mmHg、300mmHg压力下各冲洗30分钟.术中取肾组织送病理检查,监测肾单位光镜和电镜下的形态学改变;术后5天留取尿标本,应用免疫比浊测定法(ITM)检测尿微量白蛋白(ALB)和β2-微球蛋白(β-MG);并于术后第5天再次取肾组织行病理检查观察肾单位的形态学改变.结果:所有灌注组术后都出现尿蛋白的增高,术后第1天和术前相比,都有显著差异(P

Objective：To explore the influence of kidney＇s structure and function of intrapelvic perfusion under percutaneous nephrolithotripsy（PCNL）.Methods：High-pressure intrapelvic perfusion model was established under different pressure for twenty swines,to establish 24F nephrostomy established channels,in 0 mmHg（for self-control,only ostomy not perfusion）,150mmHg,200mmHg,250mmHg,300mmHg pressure for 30 minutes intrapelvic perfusion respectively.The renal biopsy specimens were used to pathologic examination and were taken for observed the morpho...