Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Xiang;Zhuang, Yuan-Yuan;Wu, Lei;Xie, Ming*;Gu, Hong-Feng;...

通讯作者：

Xie, Ming;Tang, Xiao-Qing

作者机构：

[Wang, Bo; Li, Xiang] Univ South China, Dept Anesthesiol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Tang, Xiao-Qing; Xie, Ming] Univ South China, Dept Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing; Zhuang, Yuan-Yuan; Wu, Lei] Univ South China, Inst Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang, Hunan, Peoples R China.

[Gu, Hong-Feng; Tang, Xiao-Qing; Zhuang, Yuan-Yuan; Wu, Lei] Univ South China, Key Lab Cognit Disorders & Neurodegenerat Dis, Dept Physiol, Hengyang Med Coll, Hengyang, Peoples R China.

通讯机构：

[Xie, Ming; Tang, Xiao-Qing] U

Univ South China, Dept Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Neurol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cognitive defect;Formaldehyde;Hydrogen sulfide;Brain-derived neurotrophic factor;Oxidative stress

期刊：

NEUROPSYCHOBIOLOGY

ISSN：

0302-282X

年：

2020

卷：

期：

页码：

119-130

DOI：

10.1159/000501294

基金类别：

This study was supported by National Natural Science Foundation of China (81671057, 81471310, and 81400881), the Major Research Topics of the Health and Family Planning Commission of Hunan province (A2017020), and the Key Projects of the Education Department of Hunan province (17A187).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Objective: To investigate whether hydrogen sulfide (H2S) counteracts formaldehyde (FA)-induced cognitive defects and whether the underlying mechanism is involved in the upregulation of hippocampal brain-derived neurotrophic factor (BDNF) expression. Methods: The cognitive function of rats was evaluated by the Morris water maze (MWM) test and the novel object recognition test. The content of superoxide dismutase (SOD) and malondialdehyde (MDA) in the hippocampus were detected by enzyme-linked immunosorbent assay (ELISA). The neuronal apoptosis i...

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Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor

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