Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein

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成果类型：

期刊论文

作者：

Zhong, J.;Cao, R-X;Liu, J-H;Liu, Y-B;Wang, J.;...

通讯作者：

Zu, X-Y

作者机构：

[Zhong, J.; Yang, J.; Xiao, X-H; Wen, G-B; Zu, X-Y; Cao, R-X; Liu, Y-B; Liu, L-P; Wang, J.; Zhang, Q-H; Liu, J-H; Hong, T.; Ding, W-J; Chen, Y-J; Wu, Y.] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

[Yang, J.; Xiao, X-H; Cao, R-X; Liu, J-H; Hong, T.] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Peoples R China.

通讯机构：

[Zu, X-Y] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

nuclear loss;PRMT2;cyclin D1;breast cancer

期刊：

Oncogene

ISSN：

0950-9232

年：

2014

卷：

期：

页码：

5546-5558

DOI：

10.1038/onc.2013.500

基金类别：

National Natural Science Foundation of P.R.ChinaNational Natural Science Foundation of China (NSFC) [31200573, 81272906, 81272355, 81172542]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [12JJ3116]; Education Department of Hunan Province Youth Fund [12B108]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Human protein arginine N-methyltransferase 2 (PRMT2, HRMT1L1) is a protein that belongs to the arginine methyltransferase family, and it has diverse roles in transcriptional regulation through different mechanisms depending on its binding partners. In this study, we provide evidences for the negative effect of PRMT2 on breast cancer cell proliferation in vitro and in vivo. Morever, cyclin D1, one of the key modulators of cell cycle, was found to be downregulated by PRMT2, and PRMT2 was further shown to suppress the estrogen receptor α-binding ...

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Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein

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