ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Kun;Lu, Yan-Ju;Mo, Zhong-Cheng;Liu, Xing;Tang, Zhen-Li;...

通讯作者：

Yi, Guang-Hui

作者机构：

[Jiang, Yue; Peng, Xiao-Shan; Ren, Kun; Yi, Guang-Hui; Tang, Zhen-Li] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Li; Lu, Yan-Ju] Maternal & Child Hlth Hosp Hubei Prov, Dept Pathol, Wuhan 430072, Hubei Province, Peoples R China.

[Mo, Zhong-Cheng] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Xing] Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China.

[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yi, Guang-Hui] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

HDL;S1P/S1PR2;apoA-I/SR-BI;Inflammation

期刊：

Journal of Physiology and Biochemistry

ISSN：

1138-7548

年：

2017

卷：

期：

页码：

287-296

DOI：

10.1007/s13105-017-0553-5

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270360, 81670401]; Hunan Provincial Education DepartmentHunan Provincial Education Department [13C838]; Hunan Provincial Science and Technology Department [2014FJ2012]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]; construct program of the key discipline in Hunan Province [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Endothelial dysfunction plays a vital role during the initial stage of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) induces vascular endothelial injury and vessel wall inflammation. Sphingosine-1-phosphate (S1P) exerts numerous vasoprotective effects by binding to diverse S1P receptors (S1PRs; S1PR1-5). A number of studies have shown that in endothelial cells (ECs), S1PR2 acts as a pro-atherosclerotic mediator by stimulating vessel wall inflammation through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Scavenger ...

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ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs

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