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ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs

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成果类型:
期刊论文
作者:
Ren, Kun;Lu, Yan-Ju;Mo, Zhong-Cheng;Liu, Xing;Tang, Zhen-Li;...
通讯作者:
Yi, Guang-Hui
作者机构:
[Jiang, Yue; Peng, Xiao-Shan; Ren, Kun; Yi, Guang-Hui; Tang, Zhen-Li] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
[Li, Li; Lu, Yan-Ju] Maternal & Child Hlth Hosp Hubei Prov, Dept Pathol, Wuhan 430072, Hubei Province, Peoples R China.
[Mo, Zhong-Cheng] Univ South China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.
[Liu, Xing] Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China.
[Zhang, Qing-Hai] Univ South China, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Yi, Guang-Hui] U
Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
apolipoprotein A1;endothelial nitric oxide synthase;interleukin 10;interleukin 1beta;oxidized low density lipoprotein;phosphatidylinositol 3 kinase;protein kinase B;scavenger receptor B;sphingosine 1 phosphate;sphingosine 1 phosphate receptor;sphingosine 1 phosphate receptor 2;tumor necrosis factor;unclassified drug;2-hexyl-1-cyclopentanone thiosemicarbazone;AKT1 protein, human;APOA1 protein, human;apolipoprotein A1;cyclopentane derivative;IL10 protein, human;IL1B protein, human;interleukin 10;interleukin 1beta;low density lipoprotein;lysophospholipid;phosphatidylinositol 3 kinase;protein kinase B;recombinant protein;S1PR2 protein, human;SCARB1 protein, human;scavenger receptor B;sphingosine;sphingosine 1 phosphate receptor;sphingosine 1-phosphate;thiosemicarbazone derivative;TNF protein, human;tumor necrosis factor;Article;atherosclerosis;concentration response;controlled study;cytokine release;endothelial dysfunction;enzyme activation;enzyme linked immunosorbent assay;human;human cell;in vitro study;inflammation;protein expression;signal transduction;time;umbilical vein endothelial cell;Western blotting;agonists;analogs and derivatives;antagonists and inhibitors;cell culture;chemistry;cytology;drug effects;gene expression regulation;genetics;immunology;kinetics;metabolism;nucleocytoplasmic transport;signal transduction;umbilical vein endothelial cell;vascular endothelium;Active Transport, Cell Nucleus;Apolipoprotein A-I;Cells, Cultured;Cyclopentanes;Endothelium, Vascular;Gene Expression Regulation;Human Umbilical Vein Endothelial Cells;Humans;Interleukin-10;Interleukin-1beta;Kinetics;Lipoproteins, LDL;Lysophospholipids;Phosphatidylinositol 3-Kinase;Proto-Oncogene Proteins c-akt;Receptors, Lysosphingolipid;Recombinant Proteins;Scavenger Receptors, Class B;Signal Transduction;Sphingosine;Thiosemicarbazones;Tumor Necrosis Factor-alpha
期刊:
Journal of Physiology and Biochemistry
ISSN:
1138-7548
年:
2017
卷:
73
期:
2
页码:
287-296
基金类别:
This work was sponsored by the National Natural Science Foundation of China (Nos. 81270360 and 81670401), the Scientific Research Fund of the Hunan Provincial Education Department (13C838), the Science and Technology Planning Project of the Hunan Provincial Science and Technology Department (2014FJ2012), the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (2008-244), and the construct program of the key discipline in Hunan Province (2011-76).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Endothelial dysfunction plays a vital role during the initial stage of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) induces vascular endothelial injury and vessel wall inflammation. Sphingosine-1-phosphate (S1P) exerts numerous vasoprotective effects by binding to diverse S1P receptors (S1PRs; S1PR1-5). A number of studies have shown that in endothelial cells (ECs), S1PR2 acts as a pro-atherosclerotic mediator by stimulating vessel wall inflammation through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Scavenger ...

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