The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells

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成果类型：

期刊论文

作者：

Tan, Xiaoqian;He, Yinling;Yu, Panpan;Deng, Yunong;Xie, Zhongcheng;...

通讯作者：

Peng, Tianhong;Li, Liang;Xie, W

作者机构：

[Chen, Xi; Deng, Yunong; Li, Liang; Li, Pin; Ouyang, Siyu; Tan, Xiaoqian; Peng, Tianhong; Lin, Xiaoyan; Peng, TH; Hou, Qin; Xie, Wei; Yu, Panpan; Xie, Zhongcheng; He, Yinling; Guo, Jiami; Ma, Wentao] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Tan, Xiaoqian] Xiangnan Univ, Sch Basic Med Sci, Chenzhou 423000, Hunan, Peoples R China.

[Zhu, Yunyu; Zhao, Ziye; Guo, Zilong; Zhang, Zhixia; Huang, Fei; Xie, Yushu; Guo, Zhirong; Zhang, Cen; Chen, Dandan] Univ South China, Class Clin Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, L; Xie, W ; Peng, TH] U

Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

FSP1;Ferroptosis;Necroptosis;Myristoylation;THP-1 cells;AML-M5

期刊：

MOLECULAR MEDICINE

ISSN：

1076-1551

年：

2024

卷：

期：

页码：

1-27

DOI：

10.1186/s10020-024-00861-4

基金类别：

The authors gratefully acknowledge the financial supports from the National Natural Sciences Foundation of China (81800386), the Hunan Provincial Natural Science Foundation of China (2021JJ30020), the financial supports from the scientific research project of health commission of Hunan province (202101021784), the financial supports from the science and technology plan project of Hengyang City (202150063459) and College Students’ Research Learning and Innovative Experiment Plan in University of South China (202110555098, S202110555307, X202110555516, X202110555523, X202110555529, S202210555256, 2022X10555115).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programmed cell death (PCD) serves a critical function in treatment of AML-M5. However, the role and relationship between ferroptosis and necroptosis in AML-M5 remains unclear. THP-1 cells were mainly treated with Erastin and IMP-366. The changes of ferroptosis and necroptosis levels were detected by CCK-8, western blot, quantitative real-time PCR, and ele...

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The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells

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