167株耐多药结核分枝杆菌药物敏感谱分析

首页 > 成果 > 详情

认领

导出

Link by 中国知网学术期刊 Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

论文标题(英文)：

Analysis on drug sensitivity spectrum of 167 multidrug-resistant Mycobacterium tuberculosis in China

作者：

陈蓉;李马超;赵丽丽;赵秀芹;刘海灿;...

通讯作者：

Xiuqin, Y.

作者机构：

[Xiuqin Y.] School of Public Health, University of South Ghina, Hengyang, 421001, China

[Zhiguang L.; Kanglin W.; Lili Z.; MacHao L.; Xiuqin Z.; Haican L.] State Key Laboratory for Infrctious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infrctious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China

[Yao L.] School of Laboratory Medicine and LJ Science, Iedical University, Ifenzhou, 325035, China

[Yunli D.; Rong C.; Zixin C.] School of Public Health, University of South Ghina, Hengyang, 421001, China, State Key Laboratory for Infrctious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infrctious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China

通讯机构：

[Xiuqin, Y.] S

School of Public Health, University of South Ghina, Hengyang, China

语种：

中文

关键词：

耐多药结核病;药物敏感性试验;交叉耐药;基因型

关键词(英文)：

Cross Resistance;Drug Sensitivity Test;Genotype;Multidrug-Resistant Tuberculosis

期刊：

中华流行病学杂志

ISSN：

0254-6450

年：

2020

卷：

期：

页码：

764-769

DOI：

10.3760/cma.j.cn112338-20191121-00823

基金类别：

国家科技重大专项(2018ZX10302302001005)。

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

目的:了解耐多药结核分枝杆菌的药敏谱，为耐多药结核病（MDR-TB）的临床药物选择和防控提供科学依据。方法:选取既往收集的MDR-TB 167株，采用 lysX基因测序方法进行基因分型，并采用微孔板药敏法及BACTEC TM MGIT 960 TM液体培养法对其进行13种抗结核药物的敏感性检测，分析不同基因型MDR-TB菌株与耐药表型的相关性及药物交叉耐药情况。采用 χ2检验比较计数资料组间差异。结果:167株MDR-TB菌株对除异烟肼、利福平外11种抗结核药物总耐药率为95.81%，准广泛耐药结核病（pre-XDR）比例为31.14%（52/167），广泛耐药结核病比例为6.59%（11/167）。北京基因型中链霉素耐药率高于非北京基因...

摘要(英文)：

Objective To investigate the drugs-sensitivity spectrum of multidrug-resistant tuberculosis (MDR-TB) in China and provide a scientific evidence for the drug selection in clinical therapy and the control of MDR-TB. Methods A total of 167 strains of MDR-TB were included in this study. Every strain was genotyped by lysX gene sequencing and their sensitivity to 13 different anti-TB drugs was tested by using MicroDST and BACTEC MGIT 960w liquid-culturing method. The association between drug resistance and genotypes as well as cross drug resistance w...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

167株耐多药结核分枝杆菌药物敏感谱分析

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问