Objective:To analyze the resistance mutational profiles of multi-drug resistant
Mycobacterium tuberculosis in China and the correlation between major mutation types and genotypes based on the whole-genome sequencing data.
Methods:Search and download of the genome-wide sequencing data of
M. tuberculosis published in China by August 2019 on NCBI database were conducted. Mutation frequency of drug resistance-related gene loci based on whole-genome sequencing was used to predict the molecular susceptibility of strains, and the correlation between mutation types and genotypes was analyzed.
Re...