Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy

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成果类型：

期刊论文

作者：

Wang, Futing;Deng, Suping;Song, Changxiao;Fu, Xiaofei;Zhang, Ningbo;...

通讯作者：

Cai, R

作者机构：

[Song, Changxiao; Chen, Mei; Chen, Zhuo; Wang, Futing; Zhang, Ningbo; Cai, Ren; Zhan, Jiajun; Tan, Weihong] Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensi, Changsha 410082, Peoples R China.

[Tan, Weihong] Chinese Acad Sci, Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Hangzhou Med,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200240, Peoples R China.

[Tan, Weihong] Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China.

[Yang, Hongfen; Deng, Suping] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

通讯机构：

[Cai, R ] H

Hunan Univ, Coll Mat Sci & Engn, Coll Chem & Chem Engn, Mol Sci & Biomed Lab,State Key Lab Chemo Biosensi, Changsha 410082, Peoples R China.

语种：

英文

关键词：

chemo-photothermal strategy;in situ monitoring;multifunctional Pd@Au nanoframe hydrogels;near-infrared;peroxidase-like activity

期刊：

ACS Nano

ISSN：

1936-0851

年：

2025

卷：

期：

页码：

15069-15080

DOI：

10.1021/acsnano.5c01864

基金类别：

National Natural Science Foundation of China [2024JJ5348, 2021JJ20020]; Hunan Provincial Natural Science Foundation of China [22004032]; National Natural Science Foundation of China

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

In this work, a multifunctional Pd@Au nanoframe hydrogel was designed to detect uric acid (UA) for in situ monitoring of wound infection and enhance wound healing by a chemo-photothermal strategy. In acidic conditions, the Pd@Au nanoframe hydrogels show high peroxidase-like activity by catalyzing H(2)O(2) to produce reactive oxygen species (ROS) to damage RNAs of bacteria and enhance antibacterial activity. Under Near-infrared (NIR) laser irradiation, the Pd@Au nanoframe hydrogels exhibit photothermal conversion performance; i.e., the color of ...

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Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy

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