期刊论文

Detection of Oxcarbazepine Using an Electrochemical Sensor Based on Magnetic Molecularly Imprinted Membrane

中文

分析测试学报

1004-4957

2021

40

08

1136-1144

10.19969/j.fxcsxb.20110602

国家自然科学基金资助项目（11475079）；

本校为第一机构

该文以4-乙烯基吡啶和甲基丙烯酸酯为原料制备了一种可用于检测奥卡西平（OXC）的磁性分子印迹电化学传感器（MNPs-MIP/MCPE）。首先,依据密度泛函数理论（DFT/B3LYP/6-31+G）计算,实验成功地筛选和构建出OXC与功能单体的最佳组合及比例。随后,基于沉淀聚合法合成了能够识别OXC的磁性分子印迹膜（MNPs-MIP）,将MNPs-MIP覆于碳糊电极（MCPE）表面制成MNPs-MIP/MCPE。采用差分脉冲伏安法（DPV）将MNPs-MIP/MCPE传感器用于不同浓度OXC的测定。结果显示,传感器的峰电流信号随OXC浓度的增大而增大,且OXC分别在5×10-8～3×10-6mol/L和3×10-6～1.5×10-4mol/L浓度范围内与其峰电流信号呈线性关系,其线...

In this paper,a magnetic molecularly imprinted electrochemical sensor(MNPs-MIP/MCPE)for the detection of oxcarbazepine(OXC)was prepared,using 4-vinylpyridine and methacrylate as raw materials. Firstly,according to the calculation of the density functional theory(DFT/B3LYP/6-31 + G),the best combination and the best combination ratio of the OXC with functional monomers were successfully screened and constructed. Subsequently,a magnetic molecularly imprinted membrane(MNPs-MIP)capable of recognizing OXC was synthesized based on the precipitation p...