Hydrogen sulfide prevents arecoline-induced neurotoxicity via promoting leptin/leptin receptor signaling pathway

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成果类型：

期刊论文

作者：

Cheng, Xiang;Jiang, Jia-Mei;Wang, Chun-Yan;Zou, Wei;Zhang, Ping;...

通讯作者：

Xiao-Qing Tang

作者机构：

[Cheng, Xiang] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang Med Coll, Hengyang, Hunan, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Zou, Wei; Cheng, Xiang; Jiang, Jia-Mei; Zhang, Ping] Univ South China, Hengyang Med Coll, Key Lab Cognit Disorders & Neurodegenerat Dis, Inst Neurosci, Hengyang, Hunan, Peoples R China.

[Tang, Xiao-Qing; Jiang, Jia-Mei] Univ South China, Affiliated Hosp 1, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Xiao-Qing Tang] K

Key Laboratory for Cognitive Disorders and Neurodegenerative Diseases, Institute of Neuroscience, Hengyang Medical College, University of South China, Hengyang, Hunan, P.R. China<&wdkj&>The First Affiliated Hospital, Institute of Neurology, University of South China, Hengyang, Hunan, P.R. China

语种：

英文

关键词：

arecoline;hydrogen sulfide;leptin/leptin receptor signaling pathway;neurotoxicity

期刊：

Cell Biology International

ISSN：

1065-6995

年：

2022

卷：

期：

页码：

1355-1366

DOI：

10.1002/cbin.11850

基金类别：

This study was supported by the Natural Science Foundation of Hunan Province (2020JJ4553), and the Clinical Medical Technology Innovation Guidance Project of Hunan Province (2020SK51908).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Arecoline, a major alkaloid of the areca nut, has potential toxicity to the nervous system. Our previous study reveals that the neurotoxicity of arecoline involves in inhibited endogenous hydrogen sulfide (H2S) generation. Therefore, the present study investigated whether exogenous H2S protects against arecoline-induced neurotoxicity and further explore the underlying mechanisms focusing on leptin/leptin receptor signaling pathway. The cell viability was measured by CCK-8 kit. The apoptosis were detected by Hoechst 33258 and Annexin V/PI (propidium iodide) staining. The protein expressions wer...

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Hydrogen sulfide prevents arecoline-induced neurotoxicity via promoting leptin/leptin receptor signaling pathway

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