Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zuo, Jin-Xi;Li, Min;Jiang, Li;Lan, Fang;Tang, Yi-Yun;...

通讯作者：

Zou, Wei;Tang, Xiao-Qing

作者机构：

[Li, Min; Zou, Wei; Zuo, Jin-Xi; Jiang, Li; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Peoples R China.

[Lan, Fang] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

[Tang, Xiao-Qing; Lan, Fang] Univ South China, Inst Neurol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Wang, Chun-Yan; Tang, Xiao-Qing; Kang, Xuan; Tang, Yi-Yun] Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang, Peoples R China.

通讯机构：

[Zou, Wei; Tang, Xiao-Qing] U

Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Peoples R China.

Univ South China, Inst Neurol, Affiliated Hosp 1, Hengyang, Peoples R China.

Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang, Peoples R China.

语种：

英文

关键词：

Sleep Deprivation;Hydrogen Sulfide;Hippocampal damage;Silence information regulating factor 1;Oxidative Stress

期刊：

Frontiers in Neuroscience

ISSN：

1662-4548

年：

2020

卷：

页码：

512334

DOI：

10.3389/fnins.2020.00169

基金类别：

This study was supported by the National Natural Science Foundation of China (81671057), the Major Research Topics of the Health and Family Planning Commission of Hunan province (A2017020), and the Natural Science Foundation of Hunan Province, China (2019JJ80546).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Sleep deprivation (SD) induces hippocampal damage. Hydrogen sulfide (H2S) is a neuronal protective factor. Silence information regulating factor 1 (Sirt1) plays an important role in neuroprotection. Therefore, this study was aimed at exploring whether H2S meliorates SD-induced hippocampal damage and whether Sirt1 mediates this protective role of H2S. We found that sodium hydrosulfide (NaHS, a donor of H2S) alleviated SD-generated hippocampal oxidative stress, including increases in the activation of SOD and the level of GSH as well as a decrease in the level of MDA. Meanwhile, we found that Na...

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Hydrogen Sulfide Prevents Sleep Deprivation-Induced Hippocampal Damage by Upregulation of Sirt1 in the Hippocampus

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