Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer

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成果类型：

期刊论文

作者：

Peng, Fang;Huang, Ying;Li, Mao-Yu;Li, Guo-Qing;Huang, Hui-Chao;...

通讯作者：

Chen, Yong-Heng

作者机构：

[Liang, Song-Ping; Peng, Fang] Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.

[Li, Guo-Qing; Li, Mao-Yu; Huang, Hui-Chao; Guan, Rui; Chen, Yong-Heng; Peng, Fang; Huang, Ying; Chen, Zhu-Chu] Cent South Univ, XiangYa Hosp, Minist Hlth, Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Huang, Ying] Maternal & Child Hlth Hosp Hunan Prov, Changsha 410008, Hunan, Peoples R China.

[Li, Guo-Qing] Univ South China, Sch Pharm & Life Sci, Dept Biol, Hengyang 421001, Hunan, Peoples R China.

[Guan, Rui] Hunan Canc Hosp, Ctr Med Expt, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Chen, Yong-Heng] C

Cent South Univ, XiangYa Hosp, Minist Hlth, Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Colorectal Cancer;Proteome;Biomarker;Carcinogenesis

期刊：

世界胃肠病学杂志：英文版

ISSN：

1007-9327

年：

2016

卷：

期：

页码：

4515-4528

DOI：

10.3748/wjg.v22.i18.4515

基金类别：

National "973" Project of ChinaNational Basic Research Program of China [2011CB910704]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372904, 81570537, 81272971]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

AIM: To discover novel biomarkers for early diagnosis, prognosis or treatment of human colorectal cancer. METHODS: iTRAQ 2D LC-MS/MS analysis was used to identify differentially expressed proteins (DEPs) in the human colonic epithelial carcinogenic process using laser capture microdissection-purified colonic epithelial cells from normal colon, adenoma, carcinoma in situ and invasive carcinoma tissues. RESULTS: A total of 326 DEPs were identified, and four DEPs (DMBT1, S100A9, Galectin-10, and S100A8) with progressive alteration in the carcinoge...

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Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer

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