Effect of garlic on micronuclei frequency in peripheral blood lymphocytes of rats with N-methyl-N'nitro-N-nitrosoguanidine-induced gastric carcinoma and precancerous lesions.
[Luo, Z Y; Zhang, D; Zhou, J G; Ou, Y G; Li, Y Q; Su, Q] Qi Su, Zhao-Yang Luo, Yang-Gui Ou, Yi-Qin Li, Jian-Guo Zhou, Dan Zhang, Institute of Oncology, Hengyang Medical College, Hengyang 421001, Hunan Province, China
AIM: To investigate the effects of garlic on micronuclei frequency (MNF) in peripheral blood lymphocytes (PBLs) of Wistar rats with N-methyl-N'nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinoma (GC) and precancerous lesions (PLs). METHODS: Wistar rats were exposed to MNNG at 1.25 mg/5 mL per day for 10 mo to induce GC and PLs (MNNG group, n = 30); rats not exposed to MNNG served as unmodeled controls (control group, n = 16). The MNNG rats were randomly divided into a prevention treatment group (n = 30; receiving 10 mL of a 10% garlic solution per day) and an untreated model control grou...
