We found that low‐dose IR can induce RET/PTC1 rearrangement in N‐thy‐ori‐3‐1 cell and there is a dose‐dependent manner between dose and rearrangement rate. We showed that this progress of IR‐induced RET/PTC1 rearrangement requires NHEJ and not HR. Moreover, DNA‐PKcs inhibition decreased the repair efficiency of NHEJ. Importantly, the RET/PTC1 rearrangement induced by IR was significantly decreased by DNA‐PKcs. Abstract Thyroid cancer incidence increases worldwide annually, primarily due to factors such as ionizing radiation (IR), iodin...
