I am very grateful to my PhD supervisor, Prof. Zhong-Xian Huang, of Fudan University, China, for bringing me to the field of metalloprotein design; my postdoctoral research supervisor, Prof. Yi Lu, of University of Illinois at Urbana-Champaign, USA, for inspiriting me in heme protein design; my JSPS supervisor, Prof. Shun Hirota, of Nara Institute of Science and Technology, Japan, for working on heme protein dimerization; my collaborator, Prof. Xiangshi Tan, of Fudan University, China, for long-time collaboration, and all my group members for working hard. This work by my group was supported by the National Science Foundation of China (Nos. 31370812 and 21101091), Hunan Provincial Natural Science Foundation for Distinguished Young Scholars (2015JJ1012), and Scientific Research Fund of Hunan Provincial Education Department (15A158).