期刊论文

中文

护理学杂志

1001-4152

2013

28

20

58-60

10.3870/hlxzz.2013.20.058

湖南省科技厅科技计划项目

本校为第一机构

目的探讨黄芪注射液对大鼠压疮缺血-再灌注损伤的保护作用及机制.方法将40只SD大鼠随机分为五组各8只.正常对照组、模型组在造模前腹腔注射生理盐水,黄芪注射液低、中、高剂量组造模前腹腔注射黄芪注射液2、6、10 mL/kg,每日1次,持续1周.模型组及黄芪组最后1次注药后建立缺血-再灌注损伤模型.实验结束后各组均采用苏木精-伊红染色法观察大鼠组织病理学变化,采用酶联免疫法检测血清诱导型一氧化氮合酶(iNOS)、超氧化物歧化酶(SOD)浓度.结果苏木精伊红染色显示低剂量组组织损伤程度与模型组无统计学差异(P>0.05),中、高剂量组显著轻于模型组(均P0.05);而中、高剂量组血清iNOS浓度显著低于模型组,S...

Objective To evaluate protective role and mechanism of Astragalus injection(AI)in rat subjected to ischemia-reperfusion injury.Methods Forty Sprague-Dawley rats were randomly divided into 5groups of 8.The control group was intraperitoneally injected with normal saline for a week and then sacrificed mercifully.The model group and 3 AI groups were intraperitoneally administered with normal saline,2,6,and 8mL/kg of AI respectively for a week,and then they were pressurized with the same pressure to produce ischemia-reperfusion injury.At last all the rats were sacrificed mercifully.Histopathologica...