Open Foundation of State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, China; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31200140]; Starting Foundation for High-Scientific Study of Genius from University of South China [2011XQD58]
机构署名：
本校为第一且通讯机构
院系归属：
化学化工学院
数理学院
摘要：
We have developed a uranyl-specific DNAzyme that was immobilized on the surface of a gold electrode to give a highly sensitive and selective biosensor for uranyl ion. The typical DNAzyme system consisted of the RNA (rA) as the substrate (ADNA), and the other strand is the enzyme (TDNA) with a ferrocene (Fc). The presence of uranyl ion induces the cleavage of the DNA substrate strand at the rA position to form two fragments. The Fc unit thereby is released from the surface of the electrode, and this results in a decreased peak current. This electrochemical biosensor has a dynamic range from 2 n...
