期刊论文

Yuan, Yali

英文

Microchimica Acta

0026-3672

2013

180

11-12

1059-1064

10.1007/s00604-013-1021-8

The authors gratefully acknowledge the support of the Open Foundation of State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, China, the Natural Science Foundation of China (No.31200140) and the Starting Foundation for High-Scientific Study of Genius from University of South China under the Grant 2011XQD58.

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We have developed a uranyl-specific DNAzyme that was immobilized on the surface of a gold electrode to give a highly sensitive and selective biosensor for uranyl ion. The typical DNAzyme system consisted of the RNA (rA) as the substrate (ADNA), and the other strand is the enzyme (TDNA) with a ferrocene (Fc). The presence of uranyl ion induces the cleavage of the DNA substrate strand at the rA position to form two fragments. The Fc unit thereby is released from the surface of the electrode, and this results in a decreased peak current. This elec...