Acknowledgements This work was supported by the National Natural Science Foundation of China, China (81771170) and the Hunan Provincial Natural Science Foundation of China, China (2016JJ2110; 2018JJ3465; 2018JJ2359). The funding sources had no further role.
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
A large number of studies have demonstrated that the hippocampus has important influences on stress response and memory. The abundant expressions of apelin and its receptor APJ in the hippocampus may imply potential involvement of apelin/APJ signaling in modulating stress-related memory performance deficit. In our previous study, apelin-13 ameliorates memory performance deficit in acute stressed rats. Here, we further examined whether apelin-13 can ameliorate memory performance deficit in chronic stressed rats. Rats were exposed to chronic water-immersion restraint stress (CWIRS) for 4 weeks. ...
