C16orf74 is a novel prognostic biomarker and associates with immune infiltration in head and neck squamous cell carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yao, Xiang-Rong;Xiao, Fang-Zhu;Xiao, Wen-Tao;Huang, Cui-Qin;He, Jun-Yan

通讯作者：

He, JY;Huang, CQ

作者机构：

[Yao, Xiang-Rong; He, Jun-Yan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Peoples R China.

[Yao, Xiang-Rong; Xiao, Fang-Zhu] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[Xiao, Wen-Tao] Nantong Univ, Affiliated Hosp, Med Sch, Dept Radiat Oncol, Nantong, Peoples R China.

[Huang, Cui-Qin] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Pathol, Hengyang, Peoples R China.

通讯机构：

[He, JY ; Huang, CQ ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Peoples R China.

Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Pathol, Hengyang, Peoples R China.

语种：

英文

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2025

卷：

期：

页码：

e0322701

DOI：

10.1371/journal.pone.0322701

基金类别：

National Natural Science Foundation of China [82304083]; Natural Science Foundation of Hunan Province [2023JJ40584, 2022JJ40394]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Head and neck squamous cell carcinoma (HNSC) is a prevalent and aggressive malignancy with poor prognosis, underscoring the need for novel biomarkers and therapeutic strategies. This study investigates the role of C16orf74 as a potential diagnostic and prognostic biomarker in HNSC. Bioinformatics analyses revealed that C16orf74 is significantly overexpressed in HNSC and is associated with advanced disease stages, therapy resistance, and shorter overall and progression-free survival. A prognostic nomogram integrating C16orf74 expression with clinicopathological features demonstrated robust pred...

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C16orf74 is a novel prognostic biomarker and associates with immune infiltration in head and neck squamous cell carcinoma

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