期刊论文

Chang, S.;Chang, Y.-Z.

英文

CELL DEATH & DISEASE

2041-4889

2023

14

2

10.1038/s41419-023-05688-1

This work was supported by the National Nature Science Foundation of China (Grant No. 31520103908), the National Natural Science Foundation of China (Grant No. 31900744), the Nature Science Fundation of Hebei Province, China (Grant No. E2021205003), the National Natural Science Foundation of Hebei (Grant No. C2019206575), the Science and Technology Project of Hebei Education Department (Grant No. QN2019005), the “Spark” Scientific Research Project of The First Hospital of Hebei Medical University (Grant No. XH202314), the Medical Science Research Project of Hebei Province (Grant No. 20230984) and the Project of Traditional Chinese Medicine of Hebei Province (Grant No. 2023064).

本校为其他机构

Ischemic stroke is associated with high mortality and morbidity rates worldwide. However, the molecular mechanisms underlying the neuronal damage incurred by stroke victims remain unclear. It has previously been reported that ischemic stroke can induce an increase in the levels of brain iron, which is an important factor of in the associated brain damage. Ferroportin 1 (FPN1), the only known cellular iron export protein, is found in brain microvascular endothelial cells (BMVECs) at the blood-brain barrier, and is considered the gateway for entry of plasma iron into the central nervous system. ...