The study was fiscally supported by the National Natural Science Foundation of China (grant nos. 81770490) and the Construct Program of the Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China).
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Inflammation-induced lymphangiogenesis is a widely accepted concept. However, most of the inflammatory factors and their related mechanisms have not been clarified. It has been reported that sphingosine-1-phosphate (S1P) is not only closely related to the chronic inflammatory process but also affects angiogenesis. Therefore, we investigated the inflammatory effects of S1P on human lymphatic endothelial cells (HLECs). Our results showed that S1P promotes tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) secretion in HLECs. We also confirmed that S1P-stimulated TNF-alpha...
