How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: A direct comparitive study of L29H/F43Y myoglobin

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成果类型：

期刊论文

作者：

Yan, Dao-Jing;Yuan, Hong;Li, Wei;Xiang, Yu;He, Bo;...

通讯作者：

Lin, Ying-Wu

作者机构：

[Nie, Chang-Ming; Lin, Ying-Wu; He, Bo; Yan, Dao-Jing] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Yuan, Hong; Li, Wei; Tan, Xiangshi] Fudan Univ, Shanghai Key Lab Chem Biol Prot Res, Dept Chem, Shanghai 200433, Peoples R China.

[Yuan, Hong; Li, Wei; Tan, Xiangshi] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China.

[Xiang, Yu] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.

[Wen, Ge-Bo; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.

通讯机构：

[Lin, Ying-Wu] U

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

DALTON TRANSACTIONS

ISSN：

1477-9226

年：

2015

卷：

期：

页码：

18815-18822

DOI：

10.1039/c5dt03040d

基金类别：

National Science Foundation of China, NSFCNational Natural Science Foundation of China (NSFC) [31370812, 21472027, 31270869, 11275090]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2015JJ1012]; Zhengxiang scholar program of the University of South China

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

摘要：

A heme-protein cross-link is a key post-translational modification (PTM) of heme proteins. Meanwhile, the structural and functional consequences of heme-protein cross-links are not fully understood, due to limited studies on a direct comparison of the same protein with and without the cross-link. A Tyr-heme cross-link with a C-O bond is a newly discovered PTM of heme proteins, and is spontaneously formed in F43Y myoglobin (Mb) between the Tyr hydroxyl group and the heme 4-vinyl group in vivo. In this study, we found that with an additional dist...

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How a novel tyrosine-heme cross-link fine-tunes the structure and functions of heme proteins: A direct comparitive study of L29H/F43Y myoglobin

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