期刊论文

中文

北京大学学报(医学版)

1671-167X

1999

31

6

520-523

10.3321/j.issn:1671-167X.1999.06.011

国家自然科学基金

本校为其他机构

目的：研究一氧化氮合酶（ｎｉｔｒｉｃ ｏｘｉｄｅ ｓｙｎｔｈａｓｅ， ＮＯＳ）／一氧化氮（ｎｉｃｔｒｉｃ ｏｘｉｄｅ， ＮＯ） 系统和血红素加氧酶（ｈｅｍｅ ｏｘｙｇｅｎａｓｅ，ＨＯ）／一氧化碳（ｃａｒｂｏｎ ｍｏｎｏｘｉｄｅ，ＣＯ）系统在高血压发生机制中的作用及其相互关系。方法：采用ＮＯＳ抑制剂诱导大鼠高血压模型，观察大鼠动脉血压，主动脉组织ＮＯＳ、ＨＯ 活性和ＣＯ 产生释放的变化。结果：大鼠在注射ＮＯＳ抑制剂———左旋硝基精氨酸（ＮＧｎｉｔｒｉｃＬａｒｇｉｎｉｎｅ， ＬＮＮＡ）后第４ 周血压明显增高，同时ＨＯ活性和ＨｂＣＯ形成分别增加２８ ．４％...

Objective: To investigate the interaction between endogenous carbon monoxide(CO) and nitric oxide(NO) in regulating the pathogenesis of hypertension induced by NO synthase inhibition in rats. Methods: The blood pressure of animal was measured, and the HO activity, HbCO formation and cGMP content within aortic smooth muscle tissues were examined. Results: It was suggested that blood pressure of the animal in the 4th week was significantly elevated after treatment of N G Nitric L Arginine( L NNA),an inhibitor of NO synthase, while HO activity, HbCO formation, cGMP content in plasma and tissues w...