Lipoprotein lipase (LPL) is a rate-limiting enzyme that hydrolyzes circulating triglyceride (TG)-rich lipoproteins such as very low-density lipoproteins (VLDL) and chylomicrons. A decrease in LPL activity is associated with an increase in plasma TG and a decrease in plasma high-density lipoprotein cholesterol (HDL-C). The increase in plasma TG and decrease in plasma HDL-C are risk factors for cardiovascular disease (CVD). Tsutsumi et al. hypothesized that elevating LPL activity would cause a reduction in plasma TG and an increase in plasma HDL-C, resulting in protection against the development...
