Hunan Provincial Groundbreaking Platform Open Fund of University of China [18K076]; Hunan Provincial Health Department Foundation of China [20190030]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Increasing studies have revealed that circular RNAs (circRNAs) play important roles in cancer progression. However, the potential involvement of circRNAs in breast cancer metastasis to lung is not clear so far. In this study, we conducted circular RNA microarrays of primary breast cancer tissues and lung metastatic tissues. The results revealed that circFBXL5 (hsa_circ_0125597) up-regulated the most in lung metastatic tissues. Survival analysis revealed that high levels of circFBXL5 correlated with worse outcome of breast cancer. Further experiments showed that knockdown of circFBXL5 inhibited...
