The role of N-acetyltransferases in cancers

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhu, Rongrong;Chen, Mengjiao;Luo, Yongjia;Cheng, Haipeng;Zhao, Zhenwang;...

通讯作者：

Zhang, M;Zhao, ZW

作者机构：

[Chen, Mengjiao; Zhang, Min; Zhu, Rongrong; Luo, Yongjia] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Key Lab Arteriosclerol Hunan Prov,Inst Cardiovasc, Hengyang 421001, Hunan, Peoples R China.

[Luo, Yongjia] Univ South China, Hengyang Med Sch, Dept Med, Hengyang 421001, Hunan, Peoples R China.

[Cheng, Haipeng] Cent South Univ, Xiangya Hosp 2, Dept Pathol, Changsha 410008, Hunan, Peoples R China.

[Zhao, Zhenwang; Zhao, ZW] Hubei Univ Arts & Sci, Sch Basic Med, Hlth Sci Ctr, Dept Pathol & Pathophysiol, Xiangyang 441053, Hubei, Peoples R China.

通讯机构：

[Zhao, ZW ] H

[Zhang, M ] U

Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Key Lab Arteriosclerol Hunan Prov,Inst Cardiovasc, Hengyang 421001, Hunan, Peoples R China.

Hubei Univ Arts & Sci, Sch Basic Med, Hlth Sci Ctr, Dept Pathol & Pathophysiol, Xiangyang 441053, Hubei, Peoples R China.

语种：

英文

关键词：

Acetylation;Cancer;N-acetyltransferases (NATs);N-α-acetyltransferase 10 (NAA10);Signal pathway

期刊：

Gene

ISSN：

0378-1119

年：

2024

卷：

892

页码：

147866

DOI：

10.1016/j.gene.2023.147866

基金类别：

This work was supported by the National Nature Science Foundation of China [grant number 82200086]; Natural Science Foundation of Hunan Province of China [grant number 2022JJ40678]; Research Foundation of Education Bureau of Hunan Province, China [grant number 19B490]; Natural Science Foundation of Hubei Province of China [grant number 2023AFB043].

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Cancer is a major global health problem that disrupts the balance of normal cellular growth and behavior. Mounting evidence has shown that epigenetic modification, specifically N-terminal acetylation, play a crucial role in the regulation of cell growth and function. Acetylation is a co– or post-translational modification to regulate important cellular progresses such as cell proliferation, cell cycle progress, and energy metabolism. Recently, N-acetyltransferases (NATs), enzymes responsible for acetylation, regulate signal transduction pathwa...

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The role of N-acetyltransferases in cancers

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