ETV4 promotes proliferation and invasion of lung adenocarcinoma by transcriptionally upregulating MSI2.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cheng, Tingting;Zhang, Zijian;Cheng, Yuyu;Zhang, Jing;Tang, Jianbing;...

通讯作者：

Zhou, Rongrong

作者机构：

[Cheng, Tingting] Cent S Univ, Xiangya Hosp, Dept Prevent Hlth Care, Changsha, Hunan, Peoples R China.

[Zhang, Jing; Zhou, Rongrong; Liang, Zhan; Liu, Zhiyuan; Zhang, Zijian; Chen, Taili; Li, Jiahui; Tan, Zhaohua; Cheng, Tingting; Tang, Jianbing] Cent S Univ, Xiangya Hosp, Dept Oncol, Changsha, Hunan, Peoples R China.

[Zhang, Jing; Zhou, Rongrong; Liang, Zhan; Liu, Zhiyuan; Zhang, Zijian; Chen, Taili; Li, Jiahui; Tan, Zhaohua; Tang, Jianbing] Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.

[Cheng, Yuyu] Univ South China, Chuanshan Coll, Hengyang, Peoples R China.

[Zhao, Jin] Cent S Univ, Key Lab Carcinogenesis, Chinese Minist Hlth, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

通讯机构：

[Zhou, Rongrong] C

Cent S Univ, Xiangya Hosp, Dept Oncol, Natl Clin Res Ctr Geriatr Disorders, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

ETV4;Lung adenocarcinoma;MSI2;Proliferation and invasion;Transcription regulation

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2019

卷：

516

期：

页码：

278-284

DOI：

10.1016/j.bbrc.2019.06.115

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770928]

机构署名：

本校为其他机构

院系归属：

船山学院

摘要：

The oncogenic roles of ETV4 have been revealed in multiple cancers. However, its expression and functions in lung cancer are rarely explored. Here, we firstly detected the expression of ETV4 in lung adenocarcinoma (LUAD) via online data and local experiment validation. Furthermore, we explored the functions and corresponding mechanisms of ETV4 in LUAD. Upregulation of ETV4 in LUAD is indicated by online data and our results of qPCR, Western blot and immunohistochemistry in collective tissue samples. ETV4 knockdown significantly inhibits proliferation and invasion in LUAD indicated by the outco...

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ETV4 promotes proliferation and invasion of lung adenocarcinoma by transcriptionally upregulating MSI2.

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