Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway

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成果类型：

期刊论文

作者：

Liu, Xiaochang;Huang, Xin;Luo, Jinhua;Gao, Shuai-Ning;Bai, Chenjun;...

通讯作者：

Zhou, PK;Huang, RX

作者机构：

[Huang, Xin; Luo, Jinhua; Zhou, Ping-Kun; Gao, Shuai-Ning; Liu, Xiaochang; Guan, Hua; Xie, Dafei; Gao, Shan-Shan; Bai, Chenjun] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Luo, Jinhua; Huang, RX; Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

[Gao, Shuai-Ning] Univ South China, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zhou, PK ] B

[Huang, RX ] C

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;cGAS-STING;high-fat diet;low dose radiation

期刊：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ISSN：

0925-4439

年：

2024

卷：

1870

期：

页码：

167443

DOI：

10.1016/j.bbadis.2024.167443

基金类别：

National Natural Sci-ence Foundation of China [32171238, 82173466]

机构署名：

本校为其他机构

摘要：

BACKGROUND: Atherosclerosis (AS) is the most prevalent cardiovascular disease, with an exceptionally high burden. High-fat diet (HFD) is a popular diet behavior, whereas low-dose radiation (LDR) is an environmental physical factor. There is evidence to suggest that an HFD may exacerbate the onset of atherosclerosis. Whether the combination effect of HFD and LDR would have potential on atherosclerosis development remains incompletely unclear. METHODS: In this study, ApoE(-/-) mice were used as atherosclerosis model animals to investigate the com...

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Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway

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