Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Guo, Yanan;Yan, Binjie;Gui, Yu;Tang, Zhihan;Tai, Shi;...

通讯作者：

Zhou, Shenghua;Zheng, Xi-Long

作者机构：

[Tai, Shi; Guo, Yanan; Zhou, Shenghua] Cent South Univ, Dept Cardiol, Xiangya Hosp 2, Changsha, Hunan, Peoples R China.

[Tai, Shi; Guo, Yanan; Gui, Yu; Tang, Zhihan; Zheng, Xi-Long; Yan, Binjie] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB, Canada.

[Tai, Shi; Guo, Yanan; Gui, Yu; Tang, Zhihan; Zheng, Xi-Long; Yan, Binjie] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Dept Physiol & Pharmacol, Calgary, AB, Canada.

[Tang, Zhihan; Yan, Binjie] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Zhou, Shenghua] C

[Zheng, Xi-Long] U

Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Med, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.

Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

语种：

英文

关键词：

arterial disease;autophagy;LDLR;PCSK9;vascular cells

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2021

卷：

236

期：

页码：

2333-2351

DOI：

10.1002/jcp.30025

基金类别：

Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR) [PJT-165941]; Graduate Self-Exploration and Innovation Project of Central South University [2019zzts907]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670269, 81773736]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Proprotein convertase subtilisin/kexin type-9 (PCSK9), a member of the proprotein convertase family, is an important drug target because of its crucial role in lipid metabolism. Emerging evidence suggests a direct role of localized PCSK9 in the pathogenesis of vascular diseases. With this in our consideration, we reviewed PCSK9 physiology with respect to recent development and major studies (clinical and experimental) on PCSK9 functionality in vascular disease. PCSK9 upregulates low-density lipoprotein (LDL)-cholesterol levels by binding to the LDL-receptor (LDLR) and facilitating its lysosoma...

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Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall

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