National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771170]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2016JJ2110, 2018JJ3465, 2018JJ2359]; Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2015CL025]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Localization of apelin and its receptor APJ in limbic structures such as the hippocampus suggests potential involvement of apelin/APJ signaling in stress-related emotional responses. We have recently reported that apelin-13 exerts antidepressant-like actions in acute stressed rats, and that the hippocampus is a critical brain region mediating its actions. However, the neural mechanism underling antidepressant-like actions of apelin-13 is still largely unknown. The aim of the present study is to determine whether apelin-13 ameliorates chronic water-immersion restraint stress (CWIRS)-induced dep...
