Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ning, Qjan;Liu, Yu-Feng;Ye, Peng-Ju;Gao, Pei;Li, Zhi-Ping;...

通讯作者：

Wei, Hua;Yu, Cui-Yun

作者机构：

[Wei, Hua; Li, Zhi-Ping; Ye, Peng-Ju; He, Dong-Xiu; Tang, Si-Yue; Wei, H; Yu, Cui-Yun; Tang, Sheng-Song; Ning, Qjan; Liu, Yu-Feng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Li, Zhi-Ping; Ye, Peng-Ju; He, Dong-Xiu; Tang, Si-Yue; Wei, H; Yu, Cui-Yun; Tang, Sheng-Song; Ning, Qjan; Liu, Yu-Feng] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang 421001, Peoples R China.

[Wei, Hua; Wei, H; Yu, Cui-Yun; Tang, Sheng-Song; Ning, Qjan] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

[Gao, Pei] Eastern Kentucky Univ, Chem Dept, Richmond, KY 40475 USA.

通讯机构：

[Wei, H; Yu, CY] U

[Wei, H; Yu, CY] H

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote Hunan Prov, Hengyang 421001, Peoples R China.

Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

语种：

英文

关键词：

miRNA-122;GC-FU;co-delivery;macromolecular prodrug;hepatocellular carcinoma;synergistic therapy

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2019

卷：

期：

页码：

10578-10588

DOI：

10.1021/acsami.9b00634

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471777]; Outstanding Youth Fund of Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2017111024]; Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50416]; Chuanshan Talent Program of the University of South China

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Hepatocellular carcinoma (HCC) poses a great threat to human health. The elegant combination of gene therapy and chemotherapy by nanocarriers has been repeatedly highlighted to realize enhanced therapeutic efficacy relative to monotreatment. However, the leading strategy to achieve the efficient codelivery of the gene and drug remains the electrostatic condensation with the nucleic acid and the hydrophobic encapsulation of drug molecules by the nanocarriers, which suffers substantially from premature drug leakage during circulation and severe o...

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Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma

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