Characterization of genotype IV hepatitis E virus-like particles expressed in E.coli

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成果类型：

期刊论文

作者：

Liu, Rushi;Tan, Chufan;Wu, Junwen;Xu, Ye;Li, Xiaofeng;...

通讯作者：

Qiu, YL;Feng, B

作者机构：

[Xu, Ye; Liu, Rushi; Li, Xiaofeng; Zhong, Zhihong; Tan, Chufan; Li, Sang] Hunan Normal Univ, Sch Med, Lab Med Mol & Immunol Diagnost, Changsha 410013, Peoples R China.

[Qiu, Yilan; Qiu, YL] Hunan Normal Univ, Sch Life Sci, Changsha 410081, Peoples R China.

[Wu, Junwen] Nanya Middle Sch Changsha, Changsha 410129, Peoples R China.

[Feng, Bo; Feng, B] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha 410008, Peoples R China.

通讯机构：

[Feng, B ] U

[Qiu, YL ] H

Hunan Normal Univ, Sch Life Sci, Changsha 410081, Peoples R China.

Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Hepatitis E;HEV vaccine;Virus -like particles;The recombinant capsid protein p27

期刊：

Heliyon

ISSN：

2405-8440

年：

2023

卷：

期：

页码：

e15284

DOI：

10.1016/j.heliyon.2023.e15284

基金类别：

Science and Technology Program of Changsha City [KQ1801039, KQ1907130]; National Natural Science Foundation of China [31072141]

机构署名：

本校为通讯机构

摘要：

HEV (Hepatitis E virus) is an infectious disease transmitted between humans and animals, which poses a severe threat to the biological safety and property throughout the world. The disease is especially severe in patients with potential liver cirrhosis and women during pregnancy. There is no specific and thorough HEV treatment at present. The development of hepatitis E virus vaccine is vital to the prevention of viral hepatitis worldwide. Since HEV cannot grow adequately in vitro, vaccine developed by devitalized virus particles does not work. Exploration of HEV-like structures is essential fo...

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Characterization of genotype IV hepatitis E virus-like particles expressed in E.coli

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